Progression of Parkinson's Disease and its relationship with sleep quality and functionality: Cross-sectional observational studies

Sleep quality and functionality in people with Parkinson's disease

Abstract

Background: Parkinson's disease (PD) is a progressive neurodegenerative condition that predominantly affects older individuals , with significant impacts on quality of life. It is characterized by motor symptoms, such as tremors and bradykinesia, and non-motor symptoms, such as sleep disorders. Given the complexity of PD, it is essential to deepen the analysis of the factors that interfere with quality of life, contributing to the development of integrated therapeutic strategies. Objective: To evaluate the relationship between PD progression and sleep quality and performance in activities of daily living. Methods: This is a cross-sectional observational study, conducted at the State University of Minas Gerais, involving individuals with a clinical diagnosis of PD. Participants will be recruited through a search in the Electronic Citizen Record system, in Public Health Centers of Primary Health Care in the city of Divinópolis - MG. To assess PD progression, the following tests will be conducted: the Modified Hoehn and Yahr Scale and parts I, II, and III of the Movement Disorder Society Unified PD Rating Scale (MDS-UPDRS). Sleep quality will be assessed using the Pittsburgh Sleep Quality Index (PSQI) and the Parkinson's Disease Sleep Scale (PDSS) and functionality will be assessed using the Five-Repetition Sit-to-Stand Test and the Coin Rotation Test. Discussion: The increased prevalence of PD and gaps in the literature on sleep quality and impact on ADLs may aggravate functional impairments and quality of life of these patients.